吡仑帕奈
耐受性
中止
医学
不利影响
肌萎缩侧索硬化
癫痫
利鲁唑
临床试验
内科学
麻醉
药理学
精神科
疾病
作者
Mostafa Hotait,Helen Ismail,Georges Saab,Johnny Salameh
摘要
Abstract Introduction/Aims Perampanel, a selective noncompetitive α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) antagonist, is capable of slowing the progression of the amyotrophic lateral sclerosis (ALS) phenotype and increasing the number of anterior horn cells in transgenic mice. Trials of perampanel in epilepsy showed a favorable tolerability profile. In this study we aimed to determine the tolerability and safety of perampanel in patients with ALS. Methods Enrolled subjects were started on 2 mg/day of perampanel and the dose was increased by 2 mg/day every week to a maximum dose of 8 mg/day. Our primary outcome measure was tolerability, which was evaluated by monitoring adverse events. The secondary outcome measure was clinical progression, assessed using the Amyotrophic Lateral Sclerosis Functional Rating Scale—Revised (ALSFRS‐R) and spirometry. Results Six participants were enrolled. All had adverse events, mostly behavioral. Two completed the trial and the other four withdrew due to adverse events. All participants reported resolution of these events after discontinuation of the drug. The trial was halted due to the large number of adverse events. Discussion The use of perampanel in this study of ALS was limited by its poor tolerability.
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