少突胶质细胞
再生(生物学)
细胞生物学
祖细胞
祖细胞
生物
神经科学
干细胞
髓鞘
中枢神经系统
作者
Rabia R. Khawaja,Amit Agarwal,Masahiro Fukaya,Hey-Kyeong Jeong,Scott Gross,Estíbaliz González-Fernández,Jonathan Soboloff,Dwight E. Bergles,Shin-Hyoung Kang
出处
期刊:Cell Reports
[Elsevier]
日期:2021-05-01
卷期号:35 (7): 109147-109147
被引量:17
标识
DOI:10.1016/j.celrep.2021.109147
摘要
Summary
Oligodendrocyte precursor cells (OPCs) are essential for developmental myelination and oligodendrocyte regeneration after CNS injury. These progenitors express calcium-permeable AMPA receptors (AMPARs) and form direct synapses with neurons throughout the CNS, but the roles of this signaling are unclear. To enable selective alteration of the properties of AMPARs in oligodendroglia, we generate mice that allow cell-specific overexpression of EGFP-GluA2 in vivo. In healthy conditions, OPC-specific GluA2 overexpression significantly increase their proliferation in an age-dependent manner but did not alter their rate of differentiation into oligodendrocytes. In contrast, after demyelinating brain injury in neonates or adults, higher GluA2 levels promote both OPC proliferation and oligodendrocyte regeneration, but do not prevent injury-induced initial cell loss. These findings indicate that AMPAR GluA2 content regulates the proliferative and regenerative behavior of adult OPCs, serving as a putative target for better myelin repair.
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