厚壁菌
肠道菌群
TLR4型
肾素-血管紧张素系统
脂蛋白
血管紧张素II
内科学
拟杆菌
内分泌学
生物
化学
胆固醇
医学
受体
免疫学
生物化学
基因
16S核糖体RNA
血压
作者
Amanda Souto Machado,Janaína Ribeiro Oliveira,Deborah de Farias Lelis,Victor Hugo Dantas Guimarães,Alfredo Maurício Batista de Paula,André L. S. Guimarães,Igor Viana Brandi,Bruna Mara Aparecida de Carvalho,Diego Vicente da Costa,Cláudia Regina Vieira,Ulisses Alves Pereira,Theles de Oliveira Costa,João Marcus Oliveira Andrade,Robson Augusto Souza Santos,Sérgio Henrique Sousa Santos
出处
期刊:Protein and Peptide Letters
[Bentham Science]
日期:2021-10-01
卷期号:28 (10): 1127-1137
被引量:4
标识
DOI:10.2174/0929866528666210816115645
摘要
Obesity is a serious health problem that dysregulate Renin-Angiotensin System (RAS) and intestinal microbiota.The present study aimed to evaluate the Angiotensin-(1-7) [ANG-(1-7)] oral formulation effects on obese mice intestinal microbiota.Mice were divided into four groups: obese and non-obese treated with ANG-(1-7) and obese and non-obese without ANG-(1-7) during four weeks.We observed a significant decrease in the fasting plasma glucose, total cholesterol, triglycerides, and Low-density lipoprotein levels and increased High-density lipoprotein in animals treated with ANG-(1-7). The histological analysis showed intestinal villi height reduction in mice treated with ANG-(1-7). Additionally, increased Bacteroidetes and decreased Firmicutes (increased Bacteroidetes/ Firmicutes ratio) and Enterobacter cloacae populations were observed in the High-Fat Diet + ANG-(1-7) group. Receptor toll-like 4 (TLR4) intestinal mRNA expression was reduced in the HFD+ANG-(1-7) group. Finally, the intestinal expression of the neutral amino acid transporter (B0AT1) was increased in animals treated with ANG-(1-7), indicating a possible mechanism associated with tryptophan uptake.The results of the present study suggest for the first time an interaction between oral ANG-(1-7) and intestinal microbiota modulation.
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