化学
药物发现
维生素D与神经学
药理学
维生素
药品
生物化学
计算生物学
生物
内分泌学
作者
Shinya Fujii,Yoshitomo Suhara,Hiroyuki Kagechika
出处
期刊:Biochemistry
日期:2022-03-23
标识
DOI:10.5772/intechopen.101667
摘要
In recent decades, many physiological and pharmacological functions of vitamin K other than its role as the cofactor of γ-glutamyl carboxylase (GGCX) have been identified, and consequently, many vitamin K derivatives and related congeners, including putative metabolites, have been designed and synthesized. Their biological activities include antitumor activity, anti-inflammatory activity, neuroprotective effects, neural differentiation-inducing activity, and modulating potency toward the nuclear steroid and xenobiotic receptor (SXR). These activities make vitamin K and its derivatives attractive candidates for drug discovery. In this chapter, an overview of recent advances in the medicinal chemistry of vitamin K, focusing especially on SXR modulation, neural differentiation, and antitumor activities, was provided.
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