唾液乳杆菌
唾液链球菌
益生菌
安慰剂
唾液
微生物群
医学
双歧杆菌
嗜酸乳杆菌
微生物学
内科学
免疫学
生物
胃肠病学
乳酸菌
链球菌
细菌
病理
生物信息学
遗传学
替代医学
作者
Karina Cernioglo,Karen M. Kalanetra,Anna Meier,Zachery T. Lewis,Steven A. Frese,David A. Mills,Jennifer T. Smilowitz
出处
期刊:Nutrients
[MDPI AG]
日期:2021-12-08
卷期号:13 (12): 4392-4392
被引量:2
摘要
Streptococcus salivarius (S. salivarius) K12 supplementation has been found to reduce the risk of recurrent upper respiratory tract infections. Yet, studies have not reported the effect of supplementation on oral S. salivarius K12 levels or the salivary microbiome. This clinical trial was designed to determine how supplementation with S. salivarius K12 influences the oral microbiome. In a randomized, double-blind, placebo-controlled trial, 13 healthy adults received a probiotic powder (PRO) containing Lactobacillus acidophilus, Bifidobacterium lactis, and S. salivarius K12 and 12 healthy adults received a placebo-control powder (CON) (n = 12) for 14 consecutive days. Oral S. salivarius K12 and total bacteria were quantified by qPCR and the overall oral microbiome was measured using 16S rRNA amplicon sequencing. Supplementation significantly increased mean salivary S. salivarius K12 levels by 5 logs compared to baseline for the PRO group (p < 0.0005), which returned to baseline 2 weeks post-supplementation. Compared with the CON group, salivary S. salivarius K12 was 5 logs higher in the PRO group at the end of the supplementation period (p < 0.001). Neither time nor supplementation influenced the overall oral microbiome. Supplementation with a probiotic cocktail containing S. salivarius K12 for two weeks significantly increased levels of salivary S. salivarius K12.
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