全国健康与营养检查调查
混淆
医学
贝叶斯多元线性回归
骨矿物
C反应蛋白
人口学
线性回归
多元统计
多元分析
人口
横断面研究
内科学
环境卫生
骨质疏松症
病理
数学
统计
社会学
炎症
作者
Weiran Ye,Shi Cheng,Jin Xiao,Hui Yu
标识
DOI:10.1038/s41598-022-11209-5
摘要
There was very limited evidence linking high-sensitivity C-reactive protein (HS-CRP) and total bone mineral density (BMD) in adolescents. The aim of this population-based study was to investigate the relationship between HS-CRP and total BMD in adolescents aged 10-20 years. A cross-sectional study was performed in the normal U.S. population from the data of the National Health and Nutrition Examination Survey (NHANES). The correlation between HS-CRP and total BMD was evaluated by using weighted multivariate linear regression models. And further subgroup analysis was conducted. There were 1747 participants in this study, 47.1% were female, 29.4% were white, 19.5% were black, and 22.3% were Mexican-American. In the multi-regression model that after the potential confounders had been adjusted, HS-CRP was negatively associated with total BMD. The negative association was also observed in the subgroup analyses stratified by gender and age. Our results demonstrated that higher HS-CRP was negatively correlated with total BMD in 10-20 years old adolescents.
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