Further Evidence for the Mucosal Origin of Pathogenic IgA in IgA Nephropathy

IgA nephropathy (IgAN) is defined by the glomerular deposition of IgA immune complexes. These complexes predominantly contain polymeric IgA1 that lacks galactose within its O -glycosylated hinge region, termed galactose-deficient IgA1 (GdIgA1). Circulating levels of polymeric GdIgA1 are increased in