半胱氨酸
化学生物学
化学改性
翻译后修饰
功能(生物学)
生物化学
化学
半胱氨酸代谢
蛋白质功能
计算生物学
生物
细胞生物学
酶
基因
作者
Justin M. Chalker,Gonçalo J. L. Bernardes,Yuya A. Lin,Benjamin G. Davis
标识
DOI:10.1002/asia.200800427
摘要
Abstract Cys‐tematic modification : Cysteine is a versatile amino acid for selective chemical modification of proteins. Both chemical and biological innovations made possible by cysteine modification are highlighted in this Focus Review. magnified image Chemical modification of proteins is a rapidly expanding area in chemical biology. Selective installation of biochemical probes has led to a better understanding of natural protein modification and macromolecular function. In other cases such chemical alterations have changed the protein function entirely. Additionally, tethering therapeutic cargo to proteins has proven invaluable in campaigns against disease. For controlled, selective access to such modified proteins, a unique chemical handle is required. Cysteine, with its unique reactivity, has long been used for such modifications. Cysteine has enjoyed widespread use in selective protein modification, yet new applications and even new reactions continue to emerge. This Focus Review highlights the enduring utility of cysteine in protein modification with special focus on recent innovations in chemistry and biology associated with such modifications.
科研通智能强力驱动
Strongly Powered by AbleSci AI