内分泌学
内科学
骨骼肌
线粒体生物发生
安普克
肌肉萎缩
萎缩
AMP活化蛋白激酶
线粒体
医学
生物
化学
蛋白激酶A
激酶
生物化学
作者
Won Hee Choi,Hyo Jeong Son,Young Jin Jang,Jiyun Ahn,Chang Hwa Jung,Tae-Youl Ha
标识
DOI:10.1002/mnfr.201700218
摘要
It was investigated whether apigenin (AP) protected against skeletal muscle atrophy induced by obesity.Mice were fed a high-fat diet (HFD) for 9 weeks to induce obesity, and then were assigned to two groups; the HFD group received a high-fat diet, and the HFD+AP group received a 0.1% AP-containing HFD. After additional feeding of the experimental diet for 8 weeks, mice in the HFD group were highly obese compared with the mice in the standard diet fed mice group. The mice in the AP-treated group showed less fat pad accumulation and less inflammatory cytokines without body weight reduction. The weight of skeletal muscle in the AP group tended to increase as compared with that of the HFD group. Furthermore, AP reduced the expression of atrophic genes, including MuRF1 and Atrogin-1, but increased the exercise capacity. The mitochondrial function and mitochondrial biogenesis were enhanced by AP. In cultured C2C12 cells, AP also suppressed palmitic acid-induced muscle atrophy and mitochondrial dysfunction. In addition, AP activated AMP-activated protein kinase (AMPK) in the C2C12 and the muscle of HFD-induced obese mice.The results suggested that AP ameliorated the obesity-induced skeletal muscle atrophy by attenuating mitochondrial dysfunction.
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