亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

After asthma: redefining airways diseases

哮喘 医学 小型航空公司 重症监护医学 免疫学
作者
Ian Pavord,Richard Beasley,Àlvar Agustí,Gary P. Anderson,Elisabeth H. Bel,Guy Brusselle,Paul Cullinan,Adnan Ćustović,Francine M. Ducharme,John V. Fahy,Urs Frey,Peter G. Gibson,Liam G. Heaney,Patrick G. Holt,Marc Humbert,Clare M. Lloyd,Guy B. Marks,Fernando D. Martínez,Peter D. Sly,Erika von Mutius
出处
期刊:The Lancet [Elsevier BV]
卷期号:391 (10118): 350-400 被引量:914
标识
DOI:10.1016/s0140-6736(17)30879-6
摘要

Asthma is responsible for considerable global morbidity and health-care costs. Substantial progress was made against key outcomes such as hospital admissions with asthma and mortality in the 1990s and early 2000s, but little improvement has been observed in the past 10 years, despite escalating treatment costs. New assessment techniques are not being adopted and new drug discovery has progressed more slowly than in other specialties. Transformational thinking about asthmaAlthough asthma has been recognised for thousands of years, the disorder was widely misunderstood until the 20th century.1 The first widely accepted disease definition was released only 30 years ago.2 Although this definition continues to be cited, most clinicians do not actually measure airway inflammation and hyper-responsiveness when they examine a patient with asthma. Yet most patients, clinicians, and researchers claim to recognise “asthma” when they see it—and surveillance programmes continue to document enormous morbidity and costs worldwide. Full-Text PDF Andrew Bush: a broad portfolio in paediatric respirologyAlthough it's trivial, the first thing I notice on meeting Andrew Bush is his colourful bow tie. All sorts of motives are ascribed to men who favour this form of neckwear, and few are entirely flattering. So the succeeding 40 minutes come as a relief. Far from an attention seeker, Bush is a quietly spoken and thoughtful man: a self-declared work junkie with a commitment to paediatric respirology that's equally divided between research and clinical work. “For me, they go hand in hand. It's like someone asking me if I prefer running with my right leg or my left leg. Full-Text PDF Ian Pavord: engaging with the eosinophilIt says something for Ian Pavord's modesty, self-confidence, or both that when talking of the insight with which he's most closely associated, he cheerfully volunteers that it was a rediscovery of something first noted more than 50 years ago. In the 1990s, as a consultant respiratory physician and later an honorary professor at the UK's University of Leicester, Pavord was studying eosinophils and inflammation. He'd acquired an interest in the topic during a fellowship at McMaster University in Hamilton, ON, Canada, where he worked for Freddy Hargreave, an inspirational English physician who, Pavord says, “probably trained more professors of respiratory medicine than anyone else in my era”. Full-Text PDF After asthma: airways diseases need a new name and a revolutionAsthma remains a frightening diagnosis with an unclear prognosis and outcome. The estimated global burden of asthma is substantial1 and reductions in mortality from asthma have stalled since 2006, with wide variations between countries.2 Causes are multifactorial, triggers and symptoms are varied, and the disease course over a lifetime is unpredictable. Severity can fluctuate with sudden asthma attacks leading to death in previously well controlled patients or those with very few symptoms on no medication. Full-Text PDF
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
科研通AI2S应助科研通管家采纳,获得10
1秒前
3秒前
lf发布了新的文献求助10
3秒前
lei029发布了新的文献求助10
9秒前
13秒前
14秒前
Tonyzad完成签到,获得积分10
17秒前
He发布了新的文献求助20
19秒前
江洋大盗发布了新的文献求助10
19秒前
CATH完成签到 ,获得积分10
21秒前
lei029完成签到,获得积分10
26秒前
kingJames发布了新的文献求助10
33秒前
kingJames完成签到,获得积分10
41秒前
慕青应助555557采纳,获得10
48秒前
迷路的八宝粥完成签到,获得积分10
54秒前
He完成签到,获得积分10
57秒前
休眠补正完成签到,获得积分10
1分钟前
1分钟前
snoke发布了新的文献求助30
1分钟前
李健应助太清采纳,获得10
1分钟前
1分钟前
歪歪完成签到 ,获得积分10
1分钟前
江洋大盗发布了新的文献求助10
1分钟前
黄庆勇发布了新的文献求助10
1分钟前
DPH完成签到 ,获得积分10
1分钟前
1分钟前
斯文败类应助susu采纳,获得10
1分钟前
两栖玩家完成签到 ,获得积分10
1分钟前
snoke完成签到,获得积分10
1分钟前
量子星尘发布了新的文献求助10
1分钟前
1分钟前
nanfang完成签到 ,获得积分10
1分钟前
1分钟前
2分钟前
2分钟前
2分钟前
2分钟前
共享精神应助ceeray23采纳,获得20
2分钟前
Lendar完成签到 ,获得积分10
2分钟前
2分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976619
求助须知:如何正确求助?哪些是违规求助? 3520720
关于积分的说明 11204567
捐赠科研通 3257359
什么是DOI,文献DOI怎么找? 1798716
邀请新用户注册赠送积分活动 877897
科研通“疑难数据库(出版商)”最低求助积分说明 806613