肌萎缩侧索硬化
轴浆运输
神经科学
轴突
疾病
神经退行性变
生物
医学
病理
作者
Kurt J. De Vos,Andrew J. Grierson,Steven Ackerley,Christopher C.J. Miller
出处
期刊:Annual Review of Neuroscience
[Annual Reviews]
日期:2008-06-17
卷期号:31 (1): 151-173
被引量:706
标识
DOI:10.1146/annurev.neuro.31.061307.090711
摘要
Many major human neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), display axonal pathologies including abnormal accumulations of proteins and organelles. Such pathologies highlight damage to the axon as part of the pathogenic process and, in particular, damage to transport of cargoes through axons. Indeed, we now know that disruption of axonal transport is an early and perhaps causative event in many of these diseases. Here, we review the role of axonal transport in neurodegenerative disease.
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