清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Electrical spinal-cord stimulation for painful diabetic peripheral neuropathy

医学 神经病理性疼痛 麻醉 脊髓刺激器 周围神经病变 可视模拟标度 糖尿病神经病变 硬膜外腔 腰椎 脊髓 糖尿病 刺激 外围设备 安慰剂 外科
作者
Solomon Tesfaye,Jonathan Watt,Susan M. Benbow,Kiang A. Pang,John W. Miles,Ian M. MacFarlane
出处
期刊:The Lancet [Elsevier BV]
卷期号:348 (9043): 1698-1701 被引量:259
标识
DOI:10.1016/s0140-6736(96)02467-1
摘要

Conventional treatment for painful peripheral diabetic neuropathy is largely symptomatic and often ineffective, with unacceptable side-effects. We tested electrical spinal-cord stimulation for the management of chronic neuropathic pain.Ten diabetic patients who did not respond to conventional treatment (mean age 51 [SD 9.3] years, six with type II diabetes, mean duration of diabetes 12 [6.3] years, mean duration of neuropathy 5 [2.1] years) were studied. The electrode was implanted in the thoracic/lumbar epidural space. Immediate neuropathic pain relief was assessed by visual analogue scale (VAS) after connecting the electrode, in a random order, to a percutaneous electrical stimulator or to a placebo stimulator. Exercise tolerance was assessed on a treadmill.Eight subjects had statistically significant pain relief with the electrical stimulator (p < 0.02) and were therefore converted to a permanent system. Statistically significant relief of both background and peak neuropathic pain was achieved at 3 months (n = 7, p = 0.016), at 6 months (n = 7, p = 0.03), and at the end of the study (14 months, n = 7, background pain p = 0.06, peak pain p = 0.03). One patient died 2 months after the start of the study of unrelated cause while continuing to benefit from treatment and another patient ceased to benefit at 4 months. McGill pain questionnaire scores with the stimulator turned off did not change significantly from baseline scores, indicating that the severity of the underlying pain was unaltered. However, with the stimulator turned on, there was a statistically significant (p < 0.05) improvement in all four components of the score, by the end of the study. At the end of the study, six patients continued to gain significant pain relief and used the stimulator as the sole treatment for their neuropathic pain. For example, median background and peak pain scores at the end of study, were, respectively, 77 and 81 with the stimulator off and 23 and 20 with the stimulator on. Exercise tolerance significantly improved at 3 months (n = 7, median % increase 85 [IQR, 62-360], p = 0.015) and at 6 months (n = 6, 163 [61-425], p = 0.0007). Electrophysiological tests, vibration perception-threshold, and glycaemic control were unchanged.Electrical spinal-cord stimulation offers a new and effective way of relieving chronic diabetic neuropathic pain and improves exercise tolerance. The technique should be considered in patients with neuropathic pain who do not respond to conventional treatment.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
qianci2009完成签到,获得积分10
2秒前
共享精神应助sh1ro采纳,获得10
12秒前
hahaha完成签到 ,获得积分10
12秒前
18秒前
1437594843完成签到 ,获得积分10
19秒前
清脆钧发布了新的文献求助10
24秒前
雪山飞龙完成签到,获得积分10
28秒前
牵绊完成签到 ,获得积分10
32秒前
坦率雪枫完成签到 ,获得积分10
32秒前
优秀的尔风完成签到,获得积分10
33秒前
满意机器猫完成签到 ,获得积分10
34秒前
情怀应助清脆钧采纳,获得10
39秒前
Alisha完成签到,获得积分10
40秒前
苳苳完成签到 ,获得积分10
1分钟前
1分钟前
清脆钧发布了新的文献求助10
1分钟前
小巧弘文完成签到 ,获得积分10
1分钟前
青山完成签到,获得积分10
1分钟前
清脆钧发布了新的文献求助10
1分钟前
allrubbish完成签到,获得积分10
1分钟前
墨言无殇完成签到 ,获得积分10
1分钟前
传奇3应助清脆钧采纳,获得10
2分钟前
2分钟前
丘比特应助海藏进星辰采纳,获得10
2分钟前
蝎子莱莱xth完成签到,获得积分10
2分钟前
wbh发布了新的文献求助10
2分钟前
辛勤的泽洋完成签到 ,获得积分10
2分钟前
氢锂钠钾铷铯钫完成签到,获得积分10
2分钟前
2分钟前
Square完成签到,获得积分10
2分钟前
2分钟前
2分钟前
树懒完成签到 ,获得积分10
2分钟前
2分钟前
鲑鱼完成签到 ,获得积分10
2分钟前
习月阳完成签到,获得积分10
2分钟前
乒坛巨人完成签到 ,获得积分0
3分钟前
米奇妙妙屋完成签到,获得积分10
3分钟前
liaomr完成签到 ,获得积分10
3分钟前
3分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990629
求助须知:如何正确求助?哪些是违规求助? 3532220
关于积分的说明 11256552
捐赠科研通 3271057
什么是DOI,文献DOI怎么找? 1805229
邀请新用户注册赠送积分活动 882302
科研通“疑难数据库(出版商)”最低求助积分说明 809234