四聚体
离子通道
嗅觉感受器
生物
生物物理学
细胞质
昆虫
蛋白质亚单位
细胞生物学
受体
进化生物学
遗传学
生物化学
植物
基因
酶
作者
Joel A. Butterwick,Josefina del Mármol,Kelly H. Kim,Martha A. Kahlson,Jackson A. Rogow,Thomas Walz,Vanessa Ruta
出处
期刊:Nature
[Springer Nature]
日期:2018-08-01
卷期号:560 (7719): 447-452
被引量:342
标识
DOI:10.1038/s41586-018-0420-8
摘要
The olfactory system must recognize and discriminate amongst an enormous variety of chemicals in the environment. To contend with such diversity, insects have evolved a family of odorant-gated ion channels comprised of a highly conserved co-receptor (Orco) and a divergent odorant receptor (OR) that confers chemical specificity. Here, we present the single-particle cryo-electron microscopy structure of an Orco homomer from the parasitic fig wasp Apocrypta bakeri at 3.5 Å resolution, providing structural insight into this receptor family. Orco possesses a novel channel architecture, with four subunits symmetrically arranged around a central pore that diverges into four lateral conduits that open to the cytosol. The Orco tetramer has few inter-subunit interactions within the membrane and is bound together by a small cytoplasmic anchor domain. The minimal sequence conservation among ORs maps largely to the pore and anchor domain, shedding light on how the architecture of this receptor family accommodates its remarkable sequence diversity and facilitates the evolution of odour tuning.
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