子宫内膜炎
脂多糖
乳铁蛋白
髓过氧化物酶
肿瘤坏死因子α
一氧化氮
白细胞介素
炎症
腹腔注射
化学
内科学
药理学
内分泌学
免疫学
细胞因子
生物
医学
生物化学
怀孕
遗传学
作者
Weishi Li,Kaiqiang Fu,Xiaopei Lv,Yu Wang,Jifang Wang,Huatao Li,Wenru Tian,Rongfeng Cao
标识
DOI:10.1016/j.intimp.2015.07.040
摘要
Lactoferrin (LF) is one of the most abundant proteins found in milk, and it has been reported to have anti-inflammatory properties. However, the anti-inflammatory effects of LF on lipopolysaccharide (LPS)-induced endometritis and the underlying molecular mechanisms remain to be elucidated. In this study, we evaluated the effects of LF on LPS-induced endometritis in mice. The endometritis model was established by the perfusion of mice with LPS. LF was administered by intraperitoneal injection 1h before and 12h after LPS induction. Our results demonstrated that LF significantly attenuated the histopathological changes in the uterus, reduced the activity of myeloperoxidase (MPO) and the levels of nitric oxide (NO), and inhibited the activation of NF-κB and the expression of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in a dose-dependent manner. The results suggest that LF has an anti-inflammatory effect on LPS-induced endometritis in mice. Therefore, LF may be a potential therapeutic agent for the treatment of endometritis.
科研通智能强力驱动
Strongly Powered by AbleSci AI