Increased gene expression of Toll-like receptor 4 on peripheral blood mononuclear cells in patients with psoriasis

TLR2型 外周血单个核细胞 医学 银屑病 免疫学 S100A8型 TLR9型 受体 TLR4型 白细胞介素 基因表达 Toll样受体 炎症 细胞因子 免疫系统 分子生物学 基因 先天免疫系统 内科学 生物 生物化学 DNA甲基化 体外
作者
Sonia García‐Rodríguez,Salvador Arias‐Santiago,Rubén Perandrés-López,Laura Castellote,Esther Zumaquero,Pilar Navarro,A. Buendía‐Eisman,J Ruiz,Jacinto Orgaz‐Molina,Jaime Sancho,Mercedes Zubiaur
出处
期刊:Journal of The European Academy of Dermatology and Venereology [Wiley]
卷期号:27 (2): 242-250 被引量:60
标识
DOI:10.1111/j.1468-3083.2011.04372.x
摘要

A role for the innate immune system in driving the autoimmune T cell cascade in psoriasis has been proposed. Toll-like receptors-(TLR)-2 and -4 play a role in inflammation, atherosclerosis, and their specific role in psoriasis remains unclear.To evaluate TLR2 and TLR4 gene expression levels in peripheral blood mononuclear cells from psoriatic patients.Changes in TLR2 ⁄ 4 gene expressions were evaluated using quantitative real-time reverse transcription polymerase chain reaction in peripheral blood mononuclear cells, from twenty-one patients with severe psoriasis, and analysed whether there was any correlation with cytokine plasma levels (T-helper 0-, T-helper 1-, T-helper 2- or regulatory T cells-type), or Calprotectin and with S100A8 and S100A9 gene expression levels. Eleven non-psoriatic healthy controls were analysed.A clear increase in TLR4 gene expression was observed (3.84 ± 0.93, n = 21) together with a moderate increase in TLR2 expression (1.522 ± 0.31, n = 21). Both TLR4 and TLR2 gene expressions were significantly augmented in psoriatic patients compared with controls (all P < 0.001). Correlations between TLR2 and S100A9 gene expressions (r = 0.5145, P = 0.0170, n = 21); and between TLR2 expression and plasma interleukin-2 (r = 0.5667, P = 0.0074); interleukin-4 (r = 0.4766, P = 0.0289), interleukin-10 (r = 0.4355, P = 0.0484) and interleukin-13 (r = 0.4603, P = 0.0358), were found. When patients with atheroma plaque were considered (n = 7), both TLR4 (3.47 ± 0.99, P = 0.0156) and TLR2 (1.63 ± 0.31, P = 0.0156) expressions were significantly increased vs. controls and correlated with plasma TNF-a (r = 0.8929, P = 0.0123, in both cases).Differential TLR4 ⁄ 2 gene expressions on psoriatic peripheral blood mononuclear cells and correlations with regulatory and ⁄ or proinflammatory cytokines and ⁄ or damage-associated molecular pattern molecule S100A9 emphasize innate immune response role in psoriasis.
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