The ultimate patient expectations today for implant rehabilitation are no longer just to improve function by replacing of missing teeth, but also to have the prosthetic rehabilitation appear as natural as possible (Rosenfeld et al., Int J Periodontics Restorative Dent 26:215–221, 2006). The prosthetically driven diagnosis and treatment are mandatory to achieve an optimal implant positioning and deliver the ideal prosthetic reconstruction (Rosenfeld et al., Int J Periodontics Restorative Dent 26:347–353, 2006; Rosenfeld et al., Int J Periodontics Restorative Dent 26:493–499, 2006). Full-mouth and extensive implant-supported rehabilitations must be guided by the structural architecture of the face to obtain functional and aesthetic results. The facial analysis, with all interrelated anatomic components involved in the patient smile (lips, cheeks, gingival architecture and teeth), needs to be analysed in order to deliver a successful facial and smile rejuvenation (Calamia et al., Dental Clin NA 55:187–209, 2011; Davis, Dental Clin NA 51:299–318, 2007; Spear and Kokich, Dental Clin NA 51:487–505, 2007; Giannuzzi and Motlagh, Dental Clin NA 59:609–621, 2015; Coachman et al., J Prosthet Dent 117:577–584, 2017). The purpose of this chapter is to present a systematic approach to guided surgery and prosthetic rehabilitation for the edentulous patient.