Palladium-Catalyzed Direct Oxidative Esterification of Indoles at the C3 Position: A Novel Prospect for C(sp2 )−H Acyloxylation

Abstract An efficient palladium‐catalyzed direct oxidative esterification reaction of indoles with both aliphatic and aromatic carboxylic acids is reported. The use of Ag 2 CO 3 is crucial to this transformation, as it functions as both a base and an oxidant for the regeneration of the palladium(II) catalyst. This methodology represents a novel prospect for C(sp 2 )−H acyloxylation and will promote interest in direct C(sp 2 )−H esterification.