Process Intensification Based on Disposable Solutions as First Step Toward Continuous Processing

Chapter 5 Process Intensification Based on Disposable Solutions as First Step Toward Continuous Processing Stefan R. Schmidt, Stefan R. Schmidt COO, BioAtrium AG, Operations, Lonzastrasse K02, 3930 Visp, SwitzerlandSearch for more papers by this author Stefan R. Schmidt, Stefan R. Schmidt COO, BioAtrium AG, Operations, Lonzastrasse K02, 3930 Visp, SwitzerlandSearch for more papers by this author Book Editor(s):Ganapathy Subramanian, Ganapathy Subramanian 44 Oaken Grove, SL6 6HH Berkshire, Maidenhead, United KingdomSearch for more papers by this author First published: 24 December 2021 https://doi.org/10.1002/9783527827343.ch5 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Summary Process intensification is being used primarily in the chemical industry since almost 50 years and was only recently adopted by biotechnology. The different or combined process intensification strategies should lead to simpler, more robust, and more efficient processes. Based on the depicted standard process, several entry points for the introduction of disposable solutions for process intensification can be identified. When working with a new recombinant protein, the first step certainly is process development. A wide range of different single-use bioreactors is nowadays available for perfusion and continuous processes. The chapter describes the current range of stationary phases that are available as disposable devices. Process intensification is certainly heavily influenced by the practical operations on the shop floor. However, it should be noted that process analytical technology can contribute a great deal in increasing the productivity. Process intensification can be implemented in most processes but should be evaluated already during the development. Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing RelatedInformation