液体活检
表观遗传学
癌症检测
癌症
医学
胎儿游离DNA
生物信息学
内科学
计算生物学
生物
基因
遗传学
生物化学
胎儿
产前诊断
怀孕
作者
Qiang Gao,Qiang Zeng,Zhijie Wang,Chengcheng Li,Yu Xu,Peng Cui,Zhu Xin,Huafei Lu,Guoqiang Wang,Shangli Cai,Jie Wang,Jia Fan
出处
期刊:The Innovation
[Elsevier]
日期:2022-07-01
卷期号:3 (4): 100259-100259
被引量:90
标识
DOI:10.1016/j.xinn.2022.100259
摘要
Effective screening modalities are currently available for only a small subset of cancers, and they generally have suboptimal performance with complicated procedures. Therefore, there is an urgent need to develop simple, accurate, and non-invasive methods for early detection of cancers. Genetic and epigenetic alterations in plasma circulating cell-free DNA (cfDNA) have shown the potential to revolutionize methods of early detection of cancers and facilitate subsequent diagnosis to improve survival of patients. The medical interest in cfDNA assays has been inspired by emerging single- and multi-early detection of cancers studies. This review summarizes current technological and clinical advances, in the hopes of providing insights into the development and applications of cfDNA assays in various cancers and clinical scenarios. The key phases of clinical development of biomarkers are highlighted, and the future developments of cfDNA-based liquid biopsies in early detection of cancers are outlined. It is hoped that this study can boost the potential integration of cfDNA-based early detection of cancers into the current clinical workflow.
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