光动力疗法
单线态氧
光敏剂
纳米载体
孟加拉玫瑰
聚合物囊泡
两亲性
化学
药物输送
活性氧
脂质体
纳米技术
生物物理学
材料科学
光化学
氧气
共聚物
有机化学
生物化学
生物
聚合物
作者
Krzysztof Sztandera,Michał Gorzkiewicz,Xiu Wang,Susanne Boye,Dietmar Appelhans,Barbara Klajnert‐Maculewicz
标识
DOI:10.1016/j.colsurfb.2022.112662
摘要
Photodynamic therapy is one of the best alternatives to chemo-, radio- or surgical therapy, as it is noninvasive and causes no severe side effects. The mechanism of photodynamic therapy involves activation of the drug (photosensitizer) with light of appropriate wavelength, which combined with molecular oxygen, leads to production of reactive oxygen species. This starts a cascade of reactions leading to cell death. Thus, the efficiency of this therapy is based mainly on the properties of a photosensitizer, including singlet oxygen yield and accumulation in the tumor area. Current research is aimed at applying nanosystems for the improvement of availability and photodynamic properties of photosensitizers. In order to improve the activity and increase photodynamic potential of rose bengal, one of the most promising drugs in anticancer photodynamic therapy, several drug delivery systems were developed. Among them, polymersomes represent a group of innovative polymeric vesicles mimicking membranous cell structures. Polymersomes are nanosystems made of amphiphilic block copolymers, possessing a spherical, liposome-like architecture. Within this study we present biophysical and in vitro biological characterization of this novel pH-stable nanosystem, which due to the improvement of singlet oxygen and reactive oxygen species (ROS) production by rose bengal is a good candidate for nanocarrier in photodynamic therapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI