Altered resting-state cerebral blood flow and functional connectivity mediate suicidal ideation in major depressive disorder

楔前 脑血流 重性抑郁障碍 静息状态功能磁共振成像 自杀意念 前额叶皮质 扣带回前部 神经科学 心理学 调解 内科学 医学 功能磁共振成像 心脏病学 毒物控制 认知 环境卫生 自杀预防 政治学 法学
作者
Dandan Fan,Cancan He,Xinyi Liu,Feifei Zang,Yao Zhu,Haisan Zhang,Hongxing Zhang,Zhijun Zhang,Chunming Xie
出处
期刊:Journal of Cerebral Blood Flow and Metabolism [SAGE Publishing]
卷期号:42 (9): 1603-1615 被引量:9
标识
DOI:10.1177/0271678x221090998
摘要

The relationships among cerebral blood flow (CBF), functional connectivity (FC) and suicidal ideation (SI) in major depressive disorder (MDD) patients have remained elusive. In this study, we characterized the changes in CBF and FC among 175 individuals including 47 MDD without SI (MDDNSI), 59 MDD with SI (MDDSI), and 69 healthy control (HC) who underwent arterial spin labeling and resting-state functional MRI scans. Then the voxel-wise CBF, seed-based FC and partial correlation analyses were measured. Mediation analysis was carried out to reveal the effects of FC on the association between CBF and behavioral performances in both subgroups. Results showed that CBF was higher in MDDSI patients in the bilateral precuneus compared to HC and MDDNSI participants. MDDSI patients exhibited enhanced FC in the prefrontal-limbic system and decreased FC in the sensorimotor cortex (SMC) relative to MDDNSI patients. CBF and FC were significantly correlated with clinical variables. More importantly, exploratory mediation analyses identified that abnormal FC can mediate the association between regional CBF and behavioral performances. These results highlight the potential role of precuneus gyrus, prefrontal-limbic system as well as SMC in the process of suicide and provide new insights into the neural mechanism underlying suicide in MDD patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
啦啦啦完成签到,获得积分10
刚刚
刚刚
1秒前
儒雅祥发布了新的文献求助10
2秒前
ccyy发布了新的文献求助10
2秒前
2秒前
3秒前
田様应助yl采纳,获得10
3秒前
5秒前
5秒前
tuanyz发布了新的文献求助10
5秒前
蛋黄派完成签到,获得积分10
6秒前
Czy完成签到,获得积分10
7秒前
橙是什么呈完成签到,获得积分10
8秒前
李爱国应助Wl0115采纳,获得10
9秒前
毛头完成签到,获得积分10
10秒前
Akim应助科研通管家采纳,获得10
10秒前
8R60d8应助科研通管家采纳,获得10
10秒前
Jasper应助科研通管家采纳,获得10
10秒前
10秒前
8R60d8应助科研通管家采纳,获得10
10秒前
FashionBoy应助科研通管家采纳,获得10
10秒前
SciGPT应助科研通管家采纳,获得10
11秒前
领导范儿应助科研通管家采纳,获得10
11秒前
11秒前
11秒前
11秒前
11秒前
11秒前
11秒前
11秒前
丘比特应助科研通管家采纳,获得10
11秒前
11秒前
今后应助科研通管家采纳,获得10
11秒前
w。完成签到 ,获得积分10
12秒前
13秒前
斐波拉切土豆完成签到,获得积分10
13秒前
林钰浩发布了新的文献求助10
14秒前
14秒前
Jasper应助So采纳,获得10
15秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 360
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3971333
求助须知:如何正确求助?哪些是违规求助? 3516028
关于积分的说明 11180607
捐赠科研通 3251147
什么是DOI,文献DOI怎么找? 1795693
邀请新用户注册赠送积分活动 875999
科研通“疑难数据库(出版商)”最低求助积分说明 805228