超分子化学
分子
化学
葫芦素
化学物理
量子隧道
分子识别
纳米技术
计算化学
材料科学
有机化学
光电子学
作者
Bohuai Xiao,Suhang He,Mingjun Sun,Jianghao Zhou,Zhiye Wang,Yunchuan Li,Simin Liu,Werner M. Nau,Shuai Chang
标识
DOI:10.1002/anie.202203830
摘要
We introduce a versatile recognition tunneling technique using doubly cucurbit[7]uril-functionalized electrodes to form supramolecular junctions that capture analytes dynamically by host-guest complexation. This results in characteristic changes in their single-molecule conductance. For structurally related drug molecules (camptothecin, sanguinarine, chelerythrine, and berberine) and mixtures thereof, we observed distinct current switching signals related to their intrinsic conductance properties as well as pH-dependent effects which can be traced back to their different states (protonated versus neutral). The conductance variation of a single molecule with pH shows a sigmoidal distribution, allowing us to extract a pK
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