Field experiments were conducted in 2010 and 2011 in a typical location of North China Plain to evaluate weed control efficacy of four post-emergence herbicides nicosulfuron, mesotrione, topramezone and the combination of mesotrione/nicosulfuron when they were applied at reduced doses at different weed growth stages. Experimental results showed that nicosulfuron, topramezone and the combination of mesotrione/nicosulfuron provided better weed control efficacy than mesotrione when they were applied at their label recommended doses at the 2- to 3-leaf and 4- to 5-leaf stages of weeds; nicosulfuron and mesotrione/nicosulfuron could at least be reduced by 33% and topramezone reduced by 67% without sacrificing total weed control efficacy and maize grain yield. Nicosulfuron and its combination with mesotrione could effectively control broadleaved and grass weeds when their doses were reduced by 67% and by 33%, respectively. Topramezone could effectively control broadleaved and grass weeds when its dose was reduced by 67%. The efficacy of mesotrione in controlling grass weeds was bad even at the label recommended dose. All four herbicides tested did not affect the maize grain yield.