神经氨酸酶
唾液酸
生物
凝集(生物学)
血凝
病毒学
受体
微生物学
传染性支气管炎病毒
冠状病毒
N-乙酰神经氨酸
血凝素(流感)
冠状病毒科
鸡传染性支气管炎病毒
病毒
生物化学
抗体
传染病(医学专业)
2019年冠状病毒病(COVID-19)
免疫学
医学
疾病
病理
作者
B Schultze,David R. Cavanagh,Georg Herrler
出处
期刊:Virology
[Elsevier]
日期:1992-08-01
卷期号:189 (2): 792-794
被引量:74
标识
DOI:10.1016/0042-6822(92)90608-r
摘要
The interaction of infectious bronchitis virus (IBV) with erythrocytes was analyzed. The binding activity of IBV was not sufficient to agglutinate chicken erythrocytes. However, it acquired hemagglutinating activity after treatment with neuraminidase to remove α2,3-linked N-acetylneuraminic acid from the surface of the virion. Pretreatment of erythrocytes with neuraminidase rendered the cells resistant to agglutination by IBV. Susceptibility to agglutination was restored by resialylation of asialo-erythrocytes to contain α2,3-linked sialic acid. These results indicate that IBV attaches to receptors on erythrocytes, the crucial determinant of which is sialic acid α2,3-linked to galactose. In contrast to other enveloped viruses with such a binding specificity (influenza viruses and paramyxoviruses) IBV lacks a receptor-destroying enzyme.
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