生物
细胞生物学
形态发生
微管
GTP酶
Rac-GTP结合蛋白
拟南芥
肌动蛋白
细胞骨架
细胞
信号转导
RAC1
基因
突变体
遗传学
作者
Ying Fu,Ying Gu,Zhi‐Liang Zheng,Geoffrey O. Wasteneys,Zhenbiao Yang
出处
期刊:Cell
[Elsevier]
日期:2005-03-01
卷期号:120 (5): 687-700
被引量:541
标识
DOI:10.1016/j.cell.2004.12.026
摘要
Coordinating growth and communication between adjacent cells is a critical yet poorly understood aspect of tissue development and organ morphogenesis. We report a Rho GTPase signaling network underlying the jigsaw puzzle appearance of Arabidopsis leaf pavement cells, in which localized outgrowth in one cell is coordinated with localized inhibition of outgrowth of the adjacent cell to form interdigitating lobes and indentations. Locally activated ROP2, a Rho-related GTPase from plants, activates RIC4 to promote the assembly of cortical actin microfilaments required for localized outgrowth. Meanwhile, ROP2 inactivates another target RIC1, whose activity promotes well-ordered cortical microtubules. RIC1-dependent microtubule organization not only locally inhibits outgrowth but in turn suppresses ROP2 activation in the indentation zones. Thus, outgrowth-promoting ROP2 and outgrowth-inhibiting RIC1 pathways antagonize each other. We propose that the counteractivity of these two pathways demarcates outgrowing and indenting cortical domains, coordinating a process that gives rise to interdigitations between adjacent pavement cells.
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