Three-Dimensional Porous Biodegradable Polymeric Scaffolds Fabricated with Biodegradable Hydrogel Porogens

材料科学 多孔性 可生物降解聚合物 自愈水凝胶 化学工程 复合材料 聚合物 高分子化学 工程类
作者
Jinku Kim,Michael J. Yaszemski,Lichun Lu
出处
期刊:Tissue Engineering Part C-methods [Mary Ann Liebert, Inc.]
卷期号:15 (4): 583-594 被引量:83
标识
DOI:10.1089/ten.tec.2008.0642
摘要

We have developed a new fabrication technique to create three-dimensional (3D) porous poly(epsilon-caprolactone fumarate) (PCLF) scaffolds using hydrogel microparticle porogens, as an alternative to overcome certain limitations of traditional scaffold fabrication techniques such as a salt leaching method. Both natural hydrogel, gelatin, and synthetic hydrogel, poly(ethylene glycol) sebacic acid diacrylate, were used as porogens to fabricate 3D porous PCLF scaffolds. Hydrogel microparticles were prepared by a single emulsion technique with the particle size in the range of 100-500 microm after equilibrium in water. The pore size distribution, porosity, pore interconnectivity, and spatial pore heterogeneity of the 3D PCLF scaffolds were assessed using micro-computed tomography and imaging analysis. Scaffolds fabricated with the hydrogel porogens had higher porosity and pore interconnectivity as well as more homogeneous spatial pore distribution, compared to the scaffolds made from the salt leaching process. Compressive moduli of the scaffolds were also measured and showed that lower porosity yielded greater modulus of the scaffolds. Overall, the new fabrication technology using hydrogel porogens may be beneficial for certain tissue engineering applications.
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