炎症
癌症
血管生成
免疫系统
效应器
医学
转移
生物
癌症研究
癌细胞
免疫学
肿瘤微环境
遗传学
作者
Alberto Mantovani,Paola Allavena,Antonio Sica,Frances R. Balkwill
出处
期刊:Nature
[Springer Nature]
日期:2008-07-01
卷期号:454 (7203): 436-444
被引量:9949
摘要
The mediators and cellular effectors of inflammation are important constituents of the local environment of tumours. In some types of cancer, inflammatory conditions are present before a malignant change occurs. Conversely, in other types of cancer, an oncogenic change induces an inflammatory microenvironment that promotes the development of tumours. Regardless of its origin, 'smouldering' inflammation in the tumour microenvironment has many tumour-promoting effects. It aids in the proliferation and survival of malignant cells, promotes angiogenesis and metastasis, subverts adaptive immune responses, and alters responses to hormones and chemotherapeutic agents. The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.
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