Antihypertensive effect of fosinopril, a new angiotensin converting enzyme inhibitor: findings of the Fosinopril Study Group II.

福辛普利 医学 安慰剂 血压 血管紧张素转换酶 血管紧张素转换酶抑制剂 氢氯噻嗪 内科学 泌尿科 内分泌学 病理 替代医学
作者
Pool Jl
出处
期刊:PubMed 卷期号:12 (6): 520-33 被引量:25
链接
标识
摘要

In a double-blind study, after a four- to six-week placebo period, 418 patients with mild to moderate hypertension were randomly assigned to receive 5, 10, 20, or 40 mg of fosinopril or matched placebo orally once daily for four weeks. Seated diastolic blood pressure was determined 24 hours after the most recent dose. For patients with an inadequate blood pressure response after four weeks, doses were doubled during the second four weeks, and hydrochlorothiazide was added during the final four weeks. The patients showed a significant, consistent antihypertensive response in seated and standing systolic and diastolic blood pressures after four weeks of 20 or 40 mg of fosinopril; both dosages produced similar responses. The results indicate that the dose level of fosinopril required to treat uncomplicated mild to moderate hypertension ranges from 5 to 40 mg taken once daily. Treatment was discontinued in 3% of the fosinopril patients and in 1% of the placebo patients because of side effects. No clinically significant abnormal laboratory test results were reported. Fosinoprilat, the active diacid of fosinopril, is eliminated by both the hepatobiliary and renal routes, which suggests that fosinopril may be particularly useful in the treatment of patients with impaired kidney or liver function and of elderly patients.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
xiaoxuan完成签到,获得积分10
1秒前
2秒前
Garnieta完成签到,获得积分10
3秒前
彤光赫显发布了新的文献求助10
4秒前
4秒前
浔城游侠完成签到,获得积分10
5秒前
5秒前
失眠的板栗完成签到,获得积分10
6秒前
蝶步韶华发布了新的文献求助10
8秒前
Jay发布了新的文献求助10
8秒前
jbhb发布了新的文献求助10
10秒前
幸运星发布了新的文献求助10
13秒前
13秒前
13秒前
14秒前
16秒前
小王完成签到 ,获得积分10
19秒前
liuyunhao7207发布了新的文献求助10
19秒前
Nugget发布了新的文献求助10
19秒前
量子星尘发布了新的文献求助10
22秒前
蝶步韶华完成签到,获得积分10
22秒前
SciGPT应助wade采纳,获得10
24秒前
稳重水卉完成签到,获得积分10
27秒前
我是老大应助111采纳,获得10
28秒前
30秒前
情怀应助天真的高山采纳,获得10
31秒前
万能图书馆应助高木采纳,获得10
32秒前
积极以云完成签到,获得积分10
33秒前
33秒前
35秒前
CyrusSo524应助zzz采纳,获得10
36秒前
123完成签到,获得积分10
37秒前
兔子先生完成签到 ,获得积分10
38秒前
向日葵完成签到,获得积分10
40秒前
科研通AI5应助天天采纳,获得10
40秒前
彤光赫显完成签到,获得积分10
42秒前
long0809完成签到,获得积分10
45秒前
天天快乐应助段一帆采纳,获得10
47秒前
乐乐应助江江采纳,获得10
50秒前
51秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989406
求助须知:如何正确求助?哪些是违规求助? 3531522
关于积分的说明 11254187
捐赠科研通 3270174
什么是DOI,文献DOI怎么找? 1804901
邀请新用户注册赠送积分活动 882105
科研通“疑难数据库(出版商)”最低求助积分说明 809174