Hyperreactio luteinalis is a rare condition characterized by multicystic and bilateral ovarian enlargement associated with high maternal human chorionic gonadotropin serum levels.A case of spontaneous twin pregnancy, polycystic kidney and thyrotoxicosis was treated conservatively.In this case, hyperreactio luteinalis was associated with twin pregnancy in a woman with preexisting renal failure. The association of other endocrinopathies, such as hyperthyroidism and diabetes mellitus, creates a clinical problem that could be quite hazardous in pregnancy if this association is not detected.