Brain stimulation by tDCS as treatment option in Autism Spectrum Disorder—A systematic literature review

经颅直流电刺激 心理学 自闭症谱系障碍 脑刺激 认知 背外侧前额叶皮质 自闭症 物理医学与康复 前额叶皮质 磁刺激 随机对照试验 听力学 神经科学 临床心理学 刺激 发展心理学 医学 外科
作者
Christina Luckhardt,Sara Boxhoorn,Magdalena Schütz,Nikola Fann,Christine M. Freitag
出处
期刊:Progress in Brain Research 卷期号:: 233-257 被引量:6
标识
DOI:10.1016/bs.pbr.2021.03.002
摘要

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social communication and interaction as well as stereotypical and repetitive behavior. Transcranial direct current stimulation (tDCS) has been proposed as a new intervention method in ASD with the potential to improve cognitive, motor and social communication abilities by targeting specific underlying neuronal alterations. Here, we report results of a systematic literature review on tDCS effects on EEG and behavioral outcomes, and discuss tDCS as treatment option for ASD. PsychInfo, PubMed, ScienceDirect, Web of Science, https://clinicaltrials.gov and the German Clinical Trials Register (Deutsches Register Klinischer Studien) were searched systematically for randomized, sham-controlled clinical trials of tDCS in individuals with ASD, and information regarding study designs and relevant results was extracted. Six eligible studies were identified. The dorsolateral prefrontal cortex (DLPFC) was targeted in four trials, with core ASD symptoms and working memory as outcome measures. One study targeted the primary motor cortex (M1) with motor skills as outcome, and one study targeted the temporoparietal junction (TPJ) with social communication skills as outcome measure. Comparison of the implemented study designs showed high methodological variability between studies regarding stimulation parameters, trial design and outcome measures. Study results indicate initial support for improved cognitive and social communication skills in ASD following tDCS stimulation. However, systematic and comparison studies on the best combination of stimulation intensity, duration, location as well as task related stimulation are necessary, before results can be translated into routine clinical application.
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