哮喘
医学
背景(考古学)
临床试验
重症监护医学
大流行
免疫学
透视图(图形)
哮喘管理
替代医学
2019年冠状病毒病(COVID-19)
病理
疾病
人工智能
计算机科学
传染病(医学专业)
古生物学
生物
作者
Ioana Agache,Ibon Eguíluz‐Gracia,Cătălina Cojanu,Alexandru Laculiceanu,Stefano Del Giacco,Magdalena Zemelka‐Wiącek,Anna Kosowska,Cezmi A. Akdiş,Marek Jutel
出处
期刊:Allergy
[Wiley]
日期:2021-08-29
卷期号:76 (11): 3390-3407
被引量:93
摘要
Abstract Last year brought a significant advance in asthma management, unyielding to the pressure of the pandemics. Novel key findings in asthma pathogenesis focus on the resident cell compartment, epigenetics and the innate immune system. The precision immunology unbiased approach was supplemented with novel tools and greatly facilitated by the use of artificial intelligence. Several randomised clinical trials and good quality real‐world evidence shed new light on asthma treatment and supported the revision of several asthma guidelines (GINA, Expert Panel Report 3, ERS/ATS guidelines on severe asthma) and the conception of new ones (EAACI Guidelines for the use of biologicals in severe asthma). Integrating asthma management within the broader context of Planetary Health has been put forward. In this review, recently published articles and clinical trials are summarised and discussed with the goal to provide clinicians and researchers with a concise update on asthma research from a translational perspective.
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