Nano Ag@bioactive microspheres from marine sponge Clathria frondifera: Fabrication, fortification, characterization, anticancer and antibacterial potential evaluation

海绵 抗菌活性 抗菌剂 银纳米粒子 溴化物 还原剂 化学 核化学 纳米颗粒 纳米技术 细菌 材料科学 有机化学 生物 植物 遗传学
作者
K. Saravanakumar,Manickavasagan Abinaya,Sivaraj Mehnath,Velmurugan Shanmuga Priya,Murugaraj Jeyaraj,Sarah Al-Rashed,Velluchamy Muthuraj
出处
期刊:Environmental Research [Elsevier]
卷期号:206: 112282-112282 被引量:2
标识
DOI:10.1016/j.envres.2021.112282
摘要

Bioresources are attaining much importance in the discovery of drugs and delivering agents. In particular, marine sponges are of great interest due to their metabolites production for the survival in risky environment. The incorporation of silver nanoparticles with marine sponge derived metabolites was reported for the first time. In this work, a facile material has been generated of great efficacy in solving environmental and health issues, as a recipe of silver and marine sponge Clathria frondifera, named as Ag Fortified Sponge spheres (AFS). AFS spheres were successfully synthesized after method optimization, using the various extracts of marine sponge Clathria frondifera as effective reducing agent in Ag (I) to Ag (0) reduction. Bioactive material from marine sponge and AgNP from the reduction of AgNO3 solution stablishing one another and thus AFS spheres were attaining long lifetime along with enhanced antimicrobial activity. The characterization of synthesized AFS and other AgNPs (1-4) has done using FT-IR, PXRD, FESEM, TEM, and UV-vis data. The presence of functional groups such as, Ag-O, and Ag-C stretching bonds in the AFS compounds indicated that it is composed of silver oxides and organo-silver, respectively. The synthesized Ag NPs were found to be spherical like structure with an average size of ∼20 nm. The cytotoxic response of AFS was assessed by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) and morphological changes. AFS are exact spherical, micro sized and effective in inhibiting the growth of both gram positive and gram-negative bacteria. Anticancer studies were also carried out and ensued with excellent activity in the HELA cells with potential application in the medical industry.
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