免疫系统
免疫调节
神经科学
调制(音乐)
免疫学
化学
生物
物理
声学
作者
Alexandre Kanashiro,Carlos Hiroji Hiroki,Denise Morais da Fonseca,Alexander Birbrair,Raphael Gomes Ferreira,Gabriel Shimizu Bassi,Mirian D. Fonseca,Ricardo Kusuda,Guilherme Cesar Martelossi Cebinelli,Katiussia Pinho da Silva,Carlos W. Wanderley,Gustavo Batista Menezes,José Carlos Alves-Fiho,A. G. de Oliveira,Thiago M. Cunha,André Sampaio Pupo,Luis Ulloa,Fernando Q. Cunha
标识
DOI:10.1016/j.phrs.2019.104580
摘要
Neutrophils are peripheral immune cells that represent the first recruited innate immune defense against infections and tissue injury. However, these cells can also induce overzealous responses and cause tissue damage. Although the role of neutrophils activating the immune system is well established, only recently their critical implications in neuro-immune interactions are becoming more relevant. Here, we review several aspects of neutrophils in the bidirectional regulation between the nervous and immune systems. First, the role of neutrophils as a diffuse source of acetylcholine and catecholamines is controversial as well as the effects of these neurotransmitters in neutrophil’s functions. Second, neutrophils contribute for the activation and sensitization of sensory neurons, and thereby, in events of nociception and pain. In addition, nociceptor activation promotes an axon reflex triggering a local release of neural mediators and provoking neutrophil activation. Third, the recruitment of neutrophils in inflammatory responses in the nervous system suggests these immune cells as innovative targets in the treatment of central infectious, neurological and neurodegenerative disorders. Multidisciplinary studies involving immunologists and neuroscientists are required to define the role of the neurons-neutrophils communication in the pathophysiology of infectious, inflammatory, and neurological disorders.
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