摘要
Objective
To discuss the alteration of early atherosclerosis, left ventricular myocardial hypertrophy and left heart function, and study related influencing factors about them in children metabolic syndrome(MS) patients.
Methods
The differences between the children MS group and control group in the carotid artery intima-media thickness (cIMT), left ventricular mass index (LVMI), left heart Tei index were analyzed. The correlation between cIMT, or LVMI with left heart Tei index, and the correlation between cIMT, LVMI, or Tei index with clinical data were evaluated.
Results
①The differences of cIMT[(0.59±0.06)mm vs (0.48±0.06)mm], LVMI[(65.91±11.60)g/m2 vs (52.75±13.10)g/m2], Tei index (0.33±0.04 vs 0.28±0.02) between MS group and control group were found (P<0.05). ②cIMT in MS syndrome group showed a positive correlation with body mass index(BMI), homeostasis insulin resistance(HOMA-IR), and systolic blood pressure(SBP)(r=0.741, 0.550, 0.519, P<0.05). BMI was an independent high risk factor of cIMT. ③LVMI in MS group performed a positive correlation with cIMT, HOMA-IR, BMI, SBP(r=0.798, 0.772, 0.679, 0.394, P<0.05). HOMA-IR and cIMT were independent high risk factors of LVMI.④Tei index in the MS group demonstrated a positive correlation with LVMI, BMI, cIMT, HOMA-IR(r=0.859, 0.823, 0.776, 0.747, P<0.05). BMI, LVMI were independent high risk factors of Tei index.
Conclusions
The children of MS in the present study have emerged the change of cardiovascular structure and function. Moreover, the changes of cIMT, LVMI and left heart Tei index were affected each other. In early stage of disease, to the body weight and insulin resistance index should be pay close attention to reduce the incidence of cardiovascular disease.
Key words:
Ultrasonography; Children; Metabolic syndrome