Enzymatically modified isoquercitrin improves endothelial function in volunteers at risk of cardiovascular disease

动脉硬化 安慰剂 医学 血压 槲皮素 内科学 内皮功能障碍 肱动脉 交叉研究 氧化应激 内分泌学 生物化学 化学 抗氧化剂 病理 替代医学
作者
Nicola P. Bondonno,Catherine P. Bondonno,Natalie C. Ward,Richard Woodman,Jonathan M. Hodgson
出处
期刊:British Journal of Nutrition [Cambridge University Press]
卷期号:123 (2): 182-189 被引量:20
标识
DOI:10.1017/s0007114519002137
摘要

Abstract A higher intake of food rich in flavonoids such as quercetin can reduce the risk of CVD. Enzymatically modified isoquercitrin (EMIQ ® ) has a bioavailability 17-fold higher than quercetin aglycone and has shown potential CVD moderating effects in animal studies. The present study aimed to determine whether acute ingestion of EMIQ ® improves endothelial function, blood pressure (BP) and cognitive function in human volunteers at risk of CVD. Twenty-five participants (twelve males and thirteen females) with at least one CVD risk factor completed this randomised, controlled, crossover study. In a random order, participants were given EMIQ ® (2 mg aglycone equivalent)/kg body weight or placebo alongside a standard breakfast meal. Endothelial function, assessed by flow-mediated dilatation (FMD) of the brachial artery was measured before and 1·5 h after intervention. BP, arterial stiffness, cognitive function, BP during cognitive stress and measures of quercetin metabolites, oxidative stress and markers of nitric oxide (NO) production were assessed post-intervention. After adjustment for pre-treatment measurements and treatment order, EMIQ ® treatment resulted in a significantly higher FMD response compared with the placebo (1·80 (95 % CI 0·23, 3·37) %; P = 0·025). Plasma concentrations of quercetin metabolites were significantly higher ( P < 0·001) after EMIQ ® treatment compared with the placebo. No changes in BP, arterial stiffness, cognitive function or biochemical parameters were observed. In this human intervention study, the acute administration of EMIQ ® significantly increased circulating quercetin metabolites and improved endothelial function. Further clinical trials are required to assess whether health benefits are associated with long-term EMIQ ® consumption.
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