克洛丹
并行传输
磷酸化
细胞生物学
远曲小管
生物
重吸收
紧密连接
肾
分子生物学
内分泌学
生物化学
膜
磁导率
作者
Jianghui Hou,Vijay Renigunta,Mingzhu Nie,Abby Sunq,Nina Himmerkus,Catarina Quintanova,Markus Bleich,Aparna Renigunta,Matthias T. F. Wolf
标识
DOI:10.1073/pnas.1902042116
摘要
Significance Claudin is the core protein making the tight junction and the paracellular channel. Whether it may regulate the transcellular pathway is not known. Here, we have discovered that phosphorylated claudin-16 proteins are not localized in the tight junction but found in the luminal membrane of the distal tubular cells, where they facilitate the transcellular Ca ++ permeation via Trpv5. This discovery not only resolves a longstanding mystery pertaining to the role of transcellular Ca ++ pathway in the FHHNC syndrome, but also reveals a class of functional binding partners for Trp channels.
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