纳米纤维
叶黄素
海藻酸钠
化学
钠
化学工程
材料科学
纳米技术
食品科学
有机化学
类胡萝卜素
工程类
作者
Xinxu Han,Peipei Huo,Zhongfeng Ding,Parveen Kumar,Bo Liu
出处
期刊:Pharmaceutics
[MDPI AG]
日期:2019-09-02
卷期号:11 (9): 449-449
被引量:53
标识
DOI:10.3390/pharmaceutics11090449
摘要
This investigation aims to study the characteristics and release properties of lutein-loaded polyvinyl alcohol/sodium alginate (PVA/SA) nanofibers prepared by electrospinning. In order to increase PVA/SA nanofibers' water-resistant ability for potential biomedical applications, the electrospun PVA/SA nanofibers were cross-linked with a mixture of glutaraldehyde and saturated boric acid solution at room temperature. The nanofibers were characterized using scanning electron microscopy (SEM) and X-ray diffractometer (XRD). Disintegration time and contact angle measurements testified the hydrophilicity change of the nanofibers before and after cross-linking. The lutein release from the nanofibers after cross-linking was measured by an ultraviolet absorption spectrophotometer, which showed sustained release up to 48 h and followed anomalous (non-Fickian) release mechanism as indicated by diffusion exponent value obtained from the Korsmeyer-Peppas equation. The results indicated that the prepared lutein-loaded PVA/SA nanofibers have great potential as a controlled release system.
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