化学
对称化
全合成
神经退行性变
双环分子
立体化学
有机化学
催化作用
对映选择合成
医学
病理
疾病
作者
Masayuki Inoue,Takaaki Sato,Masahiro Hirama
摘要
Merrilactone A (1) has been shown to possess neurotrophic activity and thus is expected to hold therapeutic potential in the treatment of neurodegeneration diseases. In this paper, we report the total synthesis of (+/-)-1, employing, as key steps, a novel desymmetrization protocol of meso-diketone to construct the core cis-bicyclo[3.3.0]octyl system of 1 (3 --> 2) and a radical cyclization to install the highly congested C9-quaternary carbon (16 --> 17).
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