黏膜黏附
PLGA公司
生物利用度
降级(电信)
可生物降解聚合物
离体
生物医学工程
药物输送
聚合物
材料科学
化学
药理学
作者
Zarmeena Abid,Mette Dalskov Mosgaard,Giorgio Manfroni,Ritika Singh Petersen,Line Hagner Nielsen,Anette Müllertz,Anja Boisen,Stephan Sylvest Keller
出处
期刊:Polymers
[MDPI AG]
日期:2019-11-07
卷期号:11 (11): 1828-1828
被引量:15
标识
DOI:10.3390/polym11111828
摘要
Microfabricated devices have been introduced as a promising approach to overcome some of the challenges related to oral administration of drugs and, thereby, improve their oral bioavailability. In this study, we fabricate biodegradable microcontainers with different polymers, namely poly-ɛ-caprolactone (PCL), poly(lactic-co-glycolic acid) (PLGA) 50:50 and PLGA 75:25 by hot punching. The mucoadhesion of the microcontainers is assessed with an ex vivo retention model on porcine intestinal tissue. Finally, in vitro degradation studies of the biodegradable microcontainers are completed for six weeks in simulated intestinal medium with the addition of pancreatic enzymes. Through SEM inspection, the PLGA 50:50 microcontainers show the first signs of degradation already after two weeks and complete degradation within four weeks, while the other polymers slowly degrade in the medium over several weeks.
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