糖生物学
糖蛋白组学
化学
糖基化
聚糖
糖化学
计算生物学
糖组学
糖组
生物化学
糖蛋白
生物
作者
Sachin S. Shivatare,Chi‐Huey Wong
标识
DOI:10.1021/acs.joc.0c01834
摘要
The importance of post-translational glycosylation in protein structure and function has gained significant clinical relevance recently. The latest developments in glycobiology, glycochemistry, and glycoproteomics have made the field more manageable and relevant to disease progression and immune-response signaling. Here, we summarize the current progress in glycoscience, including the new methodologies that have led to the introduction of programmable and automatic as well as large-scale enzymatic synthesis, and the development of glycan array, glycosylation probes, and inhibitors of carbohydrate-associated enzymes or receptors. These novel methodologies and tools have facilitated our understanding of the significance of glycosylation and development of carbohydrate-derived medicines that bring the field to the next level of scientific and medical significance.
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