High serum sICAM-1 is correlated with cerebral microbleeds and hemorrhagic transformation in ischemic stroke patients

医学 内科学 糖尿病 逻辑回归 冲程(发动机) 脑缺血 内皮功能障碍 ICAM-1 缺血 胃肠病学 细胞间粘附分子-1 心脏病学 炎症 细胞粘附分子 免疫学 内分泌学 机械工程 工程类
作者
Bona Wu,Jing Wu,Donglin Hao,Lun‐Lin Mao,Jin Zhang,Tingting Huang
出处
期刊:British Journal of Neurosurgery [Taylor & Francis]
卷期号:32 (6): 631-636 被引量:21
标识
DOI:10.1080/02688697.2018.1518515
摘要

Object: Intercellular adhesion molecule 1 (ICAM-1) is an adhesive protein involved in inflammatory responses and endothelial dysfunction. ICAM-1 expression is upregulated in cerebrovascular tissue affected by stroke. We investigated whether serum soluble ICAM-1 (sICAM-1) levels are associated with cerebral microbleeds (CMBs) and risk of hemorrhagic transformation (HT).Methods: 148 patients with acute ischemic stroke were enrolled. Serum sICAM-1 levels were measured and compared between patients and healthy controls. Multivariate logistic regression analysis was performed to estimate the relationship between serum sICAM-1 levels and the HT risk.Results: Serum sICAM-1 levels were significantly higher in ischemic stroke patients compared with healthy controls (p < .001), and higher in patients with CMBs (n = 81) compared with patients without CMBs (n = 67) (p < .001). Patients with high sICAM-1 levels (≥250.5 ng/mL) were more likely to have hypertension, diabetes mellitus, previous stroke, and CMBs compared with patients with low sICAM-1 levels. In stroke patients with CMBs, higher serum sICAM-1 levels were independently associated with increased HT risk.Conclusion: Serum sICAM-1 levels are associated with presence of CMBs and increased risk of HT in ischemic stroke patients.
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