医学
特发性肺纤维化
恶化
微生物群
发病机制
免疫学
疾病
呼吸系统
肺纤维化
纤维化
慢性阻塞性肺病
内科学
肺
重症监护医学
生物信息学
病理
生物
作者
Rachele Invernizzi,Philip L. Molyneaux
标识
DOI:10.1183/16000617.0045-2019
摘要
Idiopathic pulmonary fibrosis (IPF) arises in genetically susceptible individuals as a result of an aberrant wound-healing response following repetitive alveolar injury. The clinical course of the disease remains both variable and unpredictable with periods of more rapid decline, termed acute exacerbation of IPF (AE-IPF), often punctuating the disease trajectory. Exacerbations carry a significant morbidity and mortality, and their exact pathogenesis remains unclear. Given the emerging evidence that disruption and alteration in the lung microbiome plays a role in the pathogenesis and progression of IPF, this review discusses the current knowledge of the contribution of infection and the respiratory microbiome to AE-IPF.
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