趋磁细菌
纳米载体
缺氧(环境)
生物物理学
靶向给药
药品
磁小体
氧气
细菌
磁性纳米粒子
纳米颗粒
材料科学
细胞培养
化学
癌症研究
纳米技术
药物输送
生物
药理学
有机化学
遗传学
作者
Ouajdi Felfoul,Mahmood Mohammadi,Samira Taherkhani,Dominic de Lanauze,Yong Xu,Dumitru Loghin,Sherief Essa,Sylwia Jančík,Daniel Houle,Michel Lafleur,Louis Gaboury,Maryam Tabrizian,N. Kaou,Michael Atkin,T. Vuong,Gerald Batist,Nicole Beauchemin,Danuta Radzioch,Sylvain Martel
标识
DOI:10.1038/nnano.2016.137
摘要
Magnetotactic bacteria that respond to oxygen gradients can be used to carry drug payloads deep into the hypoxic regions of tumours, offering a way to improve the therapeutic index of various nanocarriers. Oxygen-depleted hypoxic regions in the tumour are generally resistant to therapies1. Although nanocarriers have been used to deliver drugs, the targeting ratios have been very low. Here, we show that the magneto-aerotactic migration behaviour2 of magnetotactic bacteria3, Magnetococcus marinus strain MC-1 (ref. 4), can be used to transport drug-loaded nanoliposomes into hypoxic regions of the tumour. In their natural environment, MC-1 cells, each containing a chain of magnetic iron-oxide nanocrystals5, tend to swim along local magnetic field lines and towards low oxygen concentrations6 based on a two-state aerotactic sensing system2. We show that when MC-1 cells bearing covalently bound drug-containing nanoliposomes were injected near the tumour in severe combined immunodeficient beige mice and magnetically guided, up to 55% of MC-1 cells penetrated into hypoxic regions of HCT116 colorectal xenografts. Approximately 70 drug-loaded nanoliposomes were attached to each MC-1 cell. Our results suggest that harnessing swarms of microorganisms exhibiting magneto-aerotactic behaviour can significantly improve the therapeutic index of various nanocarriers in tumour hypoxic regions.
科研通智能强力驱动
Strongly Powered by AbleSci AI