铜绿假单胞菌
超氧化物歧化酶
抗氧化剂
活性氧
超氧化物
过氧化氢
微生物学
氧化应激
化学
酶
生物化学
谷胱甘肽还原酶
假单胞菌
过氧化氢酶
生物
细菌
谷胱甘肽过氧化物酶
遗传学
作者
Gowthami Sampathkumar,Malika Khakimova,Tevy Chan,Dao Nguyen
标识
DOI:10.1002/9781119004813.ch46
摘要
Pseudomonas aeruginosa, an important model environmental organism and opportunistic pathogen, possesses antioxidant defenses to survive oxidative stress. Enzymatic scavengers are major defenses against the dominant reactive oxygen species, including hydrogen peroxide and superoxide anion. The stringent response, mediated by the alarmone (p)ppGpp, is induced by nutrient and other stress signals. Our studies examined the role of the stringent response in P. aeruginosa and show that expression of the catalases katA and katB, alkyl hydroperoxide reductase ahpCF, and superoxide dismutases sodA and sodB are under the control of the stringent response.
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