Protective Effect of Anesthetic Preconditioning During Ex Vivo Lung Perfusion in a Rat Lung Transplantation Model

Volatile anesthetics and opioid have been demonstrated to attenuate ischemia-reperfusion injury (IRI) in various organs. However, no previous studies have evaluated the preconditioning effect of these drugs during ex vivo lung perfusion (EVLP). Currently, we have established a rat EVLP model for four hours with stable ex vivo and post-transplant lung function. We hypothesize preconditioning with sevoflurane and/or morphine during EVLP could reduce IRI in a rat lung transplantation model.