巨噬细胞极化
巨噬细胞
肾
医学
炎症
肾病
肾小球肾炎
免疫学
急性肾损伤
糖尿病肾病
肾脏病理学
病理
内科学
生物
内分泌学
糖尿病
体外
生物化学
出处
期刊:Macrophage
[Smart Science and Technology, LLC]
日期:2015-03-30
被引量:23
标识
DOI:10.14800/macrophage.679
摘要
Macrophage accumulation associates closely with the degree of renal structural injury and renal dysfunction in human kidney diseases. Depletion of macrophages reduces while adoptive transfer of macrophages worsens inflammation in animal models of the renal injury. However, emerging evidence support that macrophage polarization plays a critical role in the progression of a number of kidney diseases including obstructive nephropathy, ischemia-reperfusion injury, glomerulonephritis, diabetic nephropathy, and other kidney diseases. In this mini-review, we briefly summarize the macrophage infiltration and polarization in these inflammatory and fibrotic kidney diseases, discussing the results mostly from studies in animal models. In view of the critical role of macrophage in the progression of these diseases, manipulating macrophage phenotype may be a potential effective strategy to treat various kidney diseases.
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