壳聚糖
明胶
止血
单宁酸
伤口愈合
止血剂
伤口敷料
柠檬酸
化学
生物医学工程
材料科学
医学
复合材料
外科
生物化学
有机化学
作者
Shujun Cao,Zhanjian Bi,Qiujing Li,Shukun Zhang,Moganavelli Singh,Jingdi Chen
标识
DOI:10.1016/j.carbpol.2023.120545
摘要
Massive damage to the skin can lead to heavy bleeding and potential wound infection. Therefore, the preparation of low-cost wound dressings that meet these requirements by simple methods has a good application prospect. In the study, a shape memory cryogel prepared at low temperatures by mixing chitosan (CS) and citric acid (CA). Silver nanoparticles (Ag NPs) introduced into the cryogel through the reduction of Ag+ with tannic acid (TA) as a reducing agent. The CS/CA/Ag cryogel has good mechanical properties and interconnected macroporous structures. The results of hemostasis tests show that CS/CA/Ag cryogel can absorb a large amount of blood and promote blood cell adhesion compared with commercial gelatin sponges and gauze. Meanwhile, CS/CA/Ag cryogel has a good antibacterial ability against S. aureus and E. coli. Furthermore, CS/CA/Ag cryogel significantly promotes wound healing in the full-thickness wound model infected with S. aureus. In conclusion, the cryogel prepared by the simple method has great advantages in rapid hemostasis and promoting wound healing.
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