生物相容性
激进的
化学
纳米颗粒
肿瘤微环境
生物物理学
体内
细胞毒性
催化作用
活性氧
癌细胞
羟基自由基
癌症治疗
体外
肿瘤细胞
纳米技术
癌症研究
生物化学
癌症
材料科学
有机化学
医学
生物
生物技术
内科学
作者
Zhenzhen Dong,Chao Yang,Zhiwei Wang,Zhangfeng Zhong,Man-Shing Wong,Hung‐Wing Li
标识
DOI:10.1016/j.smaim.2022.11.002
摘要
Chemodynamic therapy (CDT) has emerged as an effective and safe anticancer therapeutic strategy by catalytic generation of hydroxyl radicals via Fenton chemistry to kill notorious cancer cells. Herein, we decorated the Cu-based nanoparticles with pH-responsive ZnO nanoparticles to give new Zn/Cu nanoparticles (Zn/Cu NPs) which showed good biocompatibility and stability for enhanced therapeutic efficacy of CDT. The newly developed Zn/Cu NPs had a small size of ∼20 nm, which could prolong blood circulation time of NPs and facilitate their accumulation in tumor tissues. The mode of therapeutic mechanism was experimentally verified. Upon arriving at the acidic cancer cells, ZnO on Zn/Cu NPs dissolved leading to the release of Cu2+ ions which were then reduced by the overexpressed glutathione (GSH), yielding Cu+ ions. The presence of Cu+ ions favorably catalyzed the conversion of endogenous H2O2 into hydroxyl radicals by Fenton-like reactions. Such generated ROS would cause serious oxidative damage to cellular constituents resulting in cell death. Importantly, as the Zn/Cu NPs are pH sensitive, they exhibited much higher cytotoxicity against tumor cells than normal cells. In vivo studies also demonstrated that Zn/Cu NPs could effectively inhibit tumor growth without adverse side effects. Therefore, these Zn/Cu NPs hold great potential for direct and effective tumor therapy for personalized medicine applications.
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