自愈水凝胶
组织工程
纳米技术
生物相容性
材料科学
3D打印
三维打印
再生医学
药物输送
生物加工
生物医学工程
细胞外基质
3D生物打印
化学
工程类
复合材料
生物化学
高分子化学
冶金
细胞
作者
Himanshu Taneja,Sandeep M. Salodkar,Avanish Singh Parmar,Shilpi Chaudhary
标识
DOI:10.1016/j.molliq.2022.120390
摘要
Advancement in additive manufacturing has opened new avenues to serve the biomedical field, including tissue engineering. The major focus of tissue engineering is to replicate or restore the lost functions of failed organs/damaged tissues by integrating cells and biomaterials. The ease in fabrication of customized scaffolds with high precision and low material wastage are the key features of additive manufacturing over conventional methods. Recently, hydrogel materials as bio ink have shown their potential in biomedical field owing to their resemblance to extracellular matrix and biocompatibility. The application of hydrogels can be exploited for regenerative medicine, wound healing, and drug delivery. Various hydrogels find their application in tissue engineering that can be fabricated into scaffolds using a wide range of processes of additive manufacturing. However, due to the lack of structural strength, the hydrogel matrix is incorporated with different additives in order to improve overall mechanical properties. This review article gives a comprehensive overview on the use of hydrogels of different kinds, such as naturally occurring, synthetic, and composite hydrogels, as prospective bio ink materials for tissue engineering. Different sources of hydrogels, their fabrication and tissue engineering specific properties are discussed in detail. Further, the fundamental and technological challenges for additive manufacturing of hydrogel bioink material for tissue engineering are reviewed. This article will facilitate the reader with recent advancements and the current challenges in bioprinting of hydrogels for tissue engineering.
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