Construction of Spiro[indoline‐3,2′‐pyrrolo[2,1‐a]Isoquinoline] and Spiro[indoline‐3,2′‐pyrrolo[1,2‐a]Quinoline] via Isocyanide‐Based Three‐Component Reaction

Abstract A convenient synthetic protocol for novel spiro[indoline‐3,2′‐pyrrolo[2,1‐ a ]isoquinoline] and spiro[indoline‐3,2′‐pyrrolo[1,2‐ a ]quinoline] motifs was successfully developed by three‐component reaction of isoquinoline (quinoline), cyclohexyl isocyanide, and isatylidene malononitriles. In the absence of any catalyst, the three‐component reaction of isoquinoline, cyclohexyl isocyanide, and isatylidene malononitriles in refluxing dichloromethane gave functionalized spiro[indoline‐3,2′‐pyrrolo[2,1‐ a ]isoquinolines] in good yields and with high diastereoselectivity. However, the similar three‐component reaction with quinoline afforded functionalized spiro[indoline‐3,2′‐pyrrolo[1,2‐ a ]quinolines] with about 2:1 diastereoselectivity.